The corneal endothelium is a single layer of cells whose function is to maintain the balance of fluid (aqueous) within the cornea by means of a barrier effect, and to remove excess aqueous from the cornea by means of a pumping mechanism. A properly functioning endothelium maintains the correct clarity and shape of the corneal required for clear vision. When endothelial cells are lost or damaged, the remaining cells grow in size and change shape to fill in the gaps in order to maintain structural integrity. If too many cells are lost or damaged, the pumping mechanism may be negatively affected, resulting in corneal edema which may lead to partial or complete loss of vision.
Pre-Operative Risk Assessment for Cataract, Refractive and Implant Surgery
As a “predictor of success” – endothelial analysis provides critical insight for surgeons regarding the stability of the cornea that can be used to improve outcomes, manage patient expectations (especially for patients considering premium IOLs) – and mitigate potential liability.
Post-Operative Care and Co-Management
Post-operative assessment is essential to quantify surgical trauma and monitor tissue rejection from ocular surgery. Even during uneventful phacoemulsification, endothelial cell loss can be as high as 15%, therefore monitoring subsequent cell morphology during the healing process is critical. It may also be useful for monitoring signs of tissue rejection, for example post DMEK.
Contact Lens Patient Management
CellChek provides a detailed analysis of contact lens- related endotheliopathies caused by poor hygiene, low oxygen transmission or poorly fitted lenses and aids decision making for treatment plans or corrective action.
General Assessment of the Cornea
CellChek is a quick and effective method of screening for unsuspected changes and can aid the diagnosis and proper treatment of corneal diseases as such as Fuchs’ Dystrophy, keratoconus, other corneal dystrophies and trauma.